MediWound’s EscharEx Featured in Paper as a Potential Paradigm Shift Towards Non-Surgical Wound Bed Preparation in DFUs
Paper published in the
EscharEx, MediWound’s next generation topical debridement agent is a complex mixture of proteolytic enzymes enriched in bromelain developed for the treatment of chronic and other hard-to-heal wounds. Findings in the paper show EscharEx to be safe and effective, with over 50% of the patients achieving complete debridement within a week, and leaving the wounds with healthy granulation tissue. EscharEx was shown to be significantly more effective than the hydrogel control treatment. Similar results were found in the debridement of Venous Leg Ulcers (VLUs). This represents a potential paradigm shift from surgical debridement to a fast, effective, safe, practical and user-friendly treatment of chronic and hard to heal wounds.
“We were pleased to see that the physicians’ experiences highlighted in this paper are similar to the results in our other EscharEx clinical trials,” said Dr.
DFUs are open sores or wounds that if not properly treated could become infected and require hospitalization. They are likely to affect and endanger up to 34% of diabetic patients at some stage in their lives. Early and effective debridement of the devitalized tissue is a cornerstone for wound healing and even patient survival. The current standard of care is based on two alternative debridement strategies: sharp (surgical) debridement or autolytic/enzymatic (non-surgical) debridement. Sharp debridement depends on trained medical professionals and adequate medical facilities; current enzymatic debridement depends on topical agents that require weeks of treatments, numerous dressing changes and are often ineffective.
EscharEx is a bioactive therapy for debridement of chronic and other hard-to-heal wounds in advanced stages of clinical development. Designed for the outpatient setting, EscharEx is an easy-to-use concentrate of proteolytic enzymes enriched in bromelain for topical daily applications.
EscharEx was well-tolerated and demonstrated safety and efficacy in the debridement of various chronic and other hard-to-heal wounds with only few daily applications in several Phase 2 trials. EscharEx’s mechanism of action is mediated by the proteolytic enzymes that cleave and remove the necrotic tissue and prepare the wound bed for healing. A meeting with the FDA to discuss the Phase 3 pivotal study design is targeted for the fourth quarter of calendar year 2022.
MediWound is a biopharmaceutical company that develops, manufactures, and commercializes novel, cost effective, bio-therapeutic solutions for tissue repair and regeneration. Our strategy is to leverage our enzymatic technology platform, focusing on next-generation bioactive therapies for burn care, wound care, and tissue repair.
NexoBrid®, our commercial orphan biological product for non-surgical eschar removal of deep-partial and full-thickness thermal burns, is a bromelain-based biological product containing a sterile mixture of proteolytic enzymes that selectively removes burn eschar within four hours without harming surrounding viable tissue. NexoBrid is currently marketed in the European Union and other international markets and is at the registration-stage with the United States Food and Drug Administration (FDA) with a PDUFA date set as of
EscharEx® is our next-generation bioactive topical therapeutic under development in the U.S. for debridement of chronic and hard to heal wounds. EscharEx is well-tolerated and has demonstrated safety and efficacy in the debridement of various chronic and other hard-to-heal wounds within a few daily applications in several Phase 2 trials. A meeting with the FDA to discuss the Phase 3 pivotal study design is targeted for the fourth quarter of calendar year 2022.
MW005, our topical biological drug for the treatment of non-melanoma skin cancers, is a clinical-stage product candidate under development. The initial data from a Phase I/II study showed MW005 to be safe and well-tolerated, with a majority of the patients who completed the study with MW005 achieving complete clinical and histological clearance of their target lesions. The Company anticipates announcing the final data in the fourth quarter of calendar year 2022.
Committed to innovation, we are dedicated to improving standard of care and enhancing patient lives. For more information, please visit www.mediwound.com.
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Source: MediWound, Ltd.